Maki Miyamoto Selected Research

benzamide

9/2005

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

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Maki Miyamoto Research Topics

Disease

5	Neoplasms (Cancer) 10/2019 - 09/2012
4	Seizures (Absence Seizure) 01/2022 - 11/2021
3	Schizophrenia (Dementia Praecox) 01/2018 - 01/2015
3	Tuberculosis (Tuberculoses) 08/2009 - 10/2003
2	Brain Diseases (Brain Disorder) 01/2022 - 01/2022
2	Epilepsy (Aura) 01/2022 - 01/2021
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2021 - 01/2021
2	Cognitive Dysfunction 01/2018 - 01/2017
2	Medulloblastoma 09/2012 - 09/2012
1	Drug Resistant Epilepsy 01/2022
1	Sudden Unexpected Death in Epilepsy 11/2021
1	Lennox Gastaut Syndrome 01/2021
1	Dementia (Dementias) 01/2020
1	Diarrhea 01/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Memory Disorders (Memory Loss) 01/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2019
1	Extensively Drug-Resistant Tuberculosis 01/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Phototoxic Dermatitis (Phototoxicity) 01/2017
1	Central Nervous System Diseases (CNS Diseases) 01/2015
1	Huntington Disease (Huntington's Disease) 01/2015
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2014
1	Neuralgia (Stump Neuralgia) 11/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 11/2013
1	Stomach Neoplasms (Stomach Cancer) 11/2013
1	Hereditary Hemorrhagic Telangiectasia 05/2012
1	Obesity 09/2011
1	Renal Insufficiency (Renal Failure) 08/2009
1	Paragonimiasis 03/2009
1	Pulmonary Atelectasis 08/2008
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2005
1	Rheumatoid Arthritis 09/2005
1	Purpura 10/2003

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 01/2022 - 10/2003
4	soticlestatIBA 01/2022 - 01/2021
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2017 - 01/2015
3	Messenger RNA (mRNA)IBA 04/2013 - 09/2012
2	Phosphotransferases (Kinase)IBA 10/2019 - 09/2005
2	Type 2 Cyclic Nucleotide PhosphodiesterasesIBA 01/2018 - 01/2017
2	PyrazinesIBA 01/2018 - 01/2017
2	Isoniazid (Ftivazide)FDA LinkGeneric 08/2009 - 10/2003
2	Rifampin (Rifampicin)FDA LinkGeneric 08/2009 - 10/2003
1	Pentylenetetrazole (Metrazol)IBA 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Cholesterol 24-Hydroxylase (CYP46A1)IBA 11/2021
1	Scopolamine (Hyoscine)FDA Link 01/2020
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2020
1	Donepezil (Aricept)FDA LinkGeneric 01/2020
1	Cholinergic Agents (Cholinergics)IBA 01/2020
1	SynucleinsIBA 01/2020
1	AsparagineIBA 10/2019
1	Amino Acids FDA Link 10/2019
1	Asparaginase (Elspar)FDA Link 10/2019
1	TAK-915IBA 01/2018
1	RNA Precursors (Precursor, mRNA)IBA 01/2018
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2018
1	N-Methylaspartate (NMDA)IBA 01/2018
1	Antitubercular AgentsIBA 01/2017
1	Cyclic NucleotidesIBA 01/2017
1	pyrimidineIBA 01/2017
1	Pemetrexed (MTA)FDA Link 05/2014
1	Carboplatin (JM8)FDA LinkGeneric 05/2014
1	Pregabalin (Lyrica)FDA Link 11/2013
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2013
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 11/2013
1	Serotonin (5 Hydroxytryptamine)IBA 11/2013
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2013
1	TAK-441IBA 04/2013
1	Biomarkers (Surrogate Marker)IBA 04/2013
1	pyridineIBA 04/2013
1	Transcription Factors (Transcription Factor)IBA 09/2012
1	Antineoplastic Agents (Antineoplastics)IBA 09/2012
1	melanin-concentrating hormone receptorIBA 09/2011
1	Ethambutol (Myambutol)FDA LinkGeneric 08/2009
1	Prednisolone (Predate)FDA LinkGeneric 08/2009
1	Levofloxacin (Levaquin)FDA Link 08/2009
1	EnzymesIBA 03/2009
1	ImmunosorbentsIBA 03/2009
1	MitogensIBA 09/2005
1	p38 Mitogen-Activated Protein KinasesIBA 09/2005
1	Proteins (Proteins, Gene)FDA Link 09/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2005
1	benzamideIBA 09/2005
1	CytokinesIBA 09/2005
1	Inosine Triphosphate (ITP)IBA 10/2003
1	Pyrazinamide FDA LinkGeneric 10/2003

Therapy/Procedure

3	Therapeutics 11/2013 - 01/2006
2	Drug Therapy (Chemotherapy) 05/2014 - 11/2013
1	Induced Hyperthermia (Thermotherapy) 11/2021
1	Gastrectomy 11/2013
1	Stents 05/2012
1	Therapeutic Embolization 05/2012
1	X-Ray Film 08/2008
1	Steam Bath (Sauna) 01/2006